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Bacterial pathogenesis research

The continued major impact of infectious diseases results partially from an inability to deliver appropriate public health to the world's poorest countries and the emergence (and re-emergence) of infections such as Escherichia coli-mediated haemorrhagic colitis, Clostridium difficile-associated disease (CDAD) and tuberculosis in developed countries. Ongoing threats are posed by bacteria that have acquired resistance to antimicrobial agents, including species of Acinetobacter and Klebsiella that become major hospital-acquired infections here in Australia, but the rate of discovery of new antibiotics has almost halted. Since there is a clear need to broaden the number of possible antimicrobial targets, new knowledge is needed about fundamental processes of bacterial virulence and disease pathogenesis. Our program sets out to fill some of these knowledge gaps and by doing so highlight novel processes that bacteria use to cause disease, processes that in turn will become the targets for antimicrobial chemotherapy or vaccine development.

 
Postdoctoral researchers and postgraduate students

 

Major collaborators

 

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